|Identification and characterisation of novel pro-inflammatory proteases that excerbate lung disease associated with Z alpha-1 antitrypsin deficiency|
|Monday, 24 November 2008 12:25|
DA Bergin, Greene CM, Taggart CC, O’Neill SJ and McElvaney NG. Activation of the EGFR by Human Neutrophil Elastase. Royal College of Surgeons in Ireland Research Day, RCSI St. Stephen’s Green, Dublin, April 2006. DA Bergin, CM Greene, CC Taggart, EE Sterchi, SJ O’Neill, NG McElvaney.
Alpha-1 antitrypsin is an important protein produced by the liver, which is released into the bloodstream and travels to the lungs. Once inside the lungs it provides protection from the destructive effects of infections and harmful irritants, particularly tobacco smoke.
Alpha-1 antitrypsin deficiency (Alpha-1) is a genetic condition which, along with cystic fibrosis, is the commonest genetic lung disease in Ireland. It severely affects more than 2,000 people nationally, with another 10,000 individuals also at risk of lung and liver disease. It is the only proven genetic risk factor for COPD.